Amino ceramide-like compounds and therapeutic methods of use

Details Amino ceramide-like compounds and therapeutic methods of use Amino ceramide-like compounds and therapeutic methods of use

C - Chemistry, Metallurgy

07

D

C07D 211/82 (2006.01) A61K 31/164 (2006.01) A61K 31/165 (2006.01) A61P 35/00 (2006.01) C07C 233/18 (2006.01) C07D 207/04 (2006.01) C07D 207/09 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2454456

Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

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