Differential spectral topographic analysis (dista)

G - Physics – 01 – J

Patent

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G01J 3/28 (2006.01) G01N 21/19 (2006.01) G01N 21/31 (2006.01)

Patent

CA 2271206

The present invention provides a new analysis based on Differential Spectral Topographic Analysis (DISTA). Using data from the spectral methods known in the art, DISTA is based upon the normalization of the spectra to a fixed topographic space, creating a set of spectral forms, and the summation of the absolute differences in topography between one or more reference spectra and the test spectra taken at different magnitudes of the perturbing parameter. This method allows for a sensitive estimate of the fraction of form A and form B of an entity of interest. This method also allows for the calculation of apparent free energy from the conversion of the entity of interest from a first to a second form where appropriate, and in the alternative, calculation of a fraction of structural changes.

La présente invention concerne une nouvelle technique d'analyse reposant sur le principe de l'analyse DISTA ou analyse topographique spectrale différentielle (Differential Spectral Topographic Analysis). Utilisant des données obtenues au moyen des techniques spectrales connues, l'analyse DISTA consiste à normaliser des spectres pour donner un espace topographique figé, à créer un ensemble de forme spectrales, et à faire la sommation des différences absolues de topographie entre un ou plusieurs spectres de référence, les spectres des tests étant pris pour différentes grandeurs du paramètre perturbateur. Cette technique permet d'obtenir avec un niveau élevé de sensibilité une évaluation de la fraction de forme A et de la fraction de forme B d'une entité étudiée. Cette technique permet également, le cas échéant, de calculer l'énergie libre apparente issue de la conversion de l'entité étudiée pour passer de la première forme à la seconde forme, ou sinon, de calculer une fraction se rapportant à des modifications structurelles.

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