Use of thiazole derivatives for preparing a medicine for...

Details Use of thiazole derivatives for preparing a medicine for... Use of thiazole derivatives for preparing a medicine for...

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2455635

The invention concerns compounds of general formula (I), wherein: A represents one of the radicals in which R?5¿ represents independently a hydrogen atom, or alkyl; R?6¿, R?7¿ and R?8¿ independently represent a hydrogen atom, alkyl, cycloalkyl, hydroxy or alkoxy; R?11¿ represents a hydrogen atom of alkyl; and R?9¿, R?10¿ and R?12¿ independently represent a hydrogen atom, alkyl, hydroxy or alkoxy; B represents a hydrogen atom or alkyl; n represents an integer from 0 to 5; R?1¿ and R?2¿ independently represent a hydrogen atom, alkyl or cycloalkyl; R?3¿ and R?4¿ independently represent a hydrogen atom or an alkyl radical, or R?3¿ and R?4¿ together form with the nitrogen atom which bears them a heterocycle optionally substituted comprising in all 1 to 2 heteroatoms and 5 to 7 members. Said compounds can be used for preparing a medicine for protecting mitochondria, and in particular a medicine for preventing or treating cirrhosis.

Selon l'invention, les composes de formule générale (I), dans laquelle A représente l'un des radicaux dans lesquels R5 représente un atome d'hydrogène ou alkyle, R6, R7 et R8 représentent indépendamment un atome d 'hydrogène, alkyle, cycloalkyle, hydroxy ou alkoxy, R 11 représente un atome d'hydrogène ou alkyle et R9, R1O et R12 représentent indépendamment un atome d'hydrogène, alkyle, hydroxy ou alkoxy ; B représente un atome d'hydrogène ou alkyle ; n représente un entier de O a 5 ; R1 et R2 représentent indépendamment un atome d'hydrogène, alkyle ou cycloalkyle ; R3 et R4 représentent indépendamment un atome d'hydrogène ou un radical alkyle, ou bien R3 et R4 forment ensemble avec l'atome d'azote qui les porte un hétérocycle éventuellement substitue comptant en tout de 1 a 2 hétéroatomes et de 5 a 7 chaînons ; peuvent être utilises pour préparer un médicament destine a protéger les mitochondries, et en particulier un méicament destiné a prévenir ou a traiter la cirrhose du foie.

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