Anti-bacterial drug targeting of genome maintenance interfaces

Details Anti-bacterial drug targeting of genome maintenance interfaces Anti-bacterial drug targeting of genome maintenance interfaces

A - Human Necessities

61

K

A61K 31/428 (2006.01) A61K 31/426 (2006.01) A61K 45/00 (2006.01) A61L 2/16 (2006.01) A61P 31/04 (2006.01) G01N 33/53 (2006.01) C07K 14/195 (2006.01) C12N 9/22 (2006.01) C12Q 1/44 (2006.01) C30B 29/58 (2006.01)

Patent

CA 2684873

Methods for the design and identification of novel antimicrobial compounds are provided, as well as antimicrobial compounds identified using these methods. Pharmaceutical compositions that include these antimicrobial compounds are provided as well. The antimicrobial compounds inhibit the binding of a prokaryotic single-stranded DNA binding protein to a polypeptide. In some examples, the prokaryotic single-stranded DNA binding protein is prokaryotic exonuclease I.

La présente invention concerne des procédés de conception et d'identification de nouveaux composés antimicrobiens, ainsi que des composés antimicrobiens identifiés par ces procédés. L'invention concerne également des compositions pharmaceutiques les contenant. Les composés antimicrobiens inhibent la liaison d'une protéine de liaison à ADN simple brin procaryote à un polypeptide. Dans certains exemples, la protéine de liaison à ADN simple brin procaryote est l'exonucléase I procaryote.

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