Substituted phenylpropionic acid derivatives as agonists to...

Details Substituted phenylpropionic acid derivatives as agonists to... Substituted phenylpropionic acid derivatives as agonists to...

C - Chemistry, Metallurgy

07

C

C07C 235/20 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 45/06 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2470491

The present invention provides the S enantiomer of a compound of formula (I) wherein n is 1 or 2 as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

L'invention concerne un énantiomère S d'un composé de formule (I), dans laquelle n représente 1 ou 2, ainsi que leurs sels pharmaceutiquement acceptables, leurs solvates, leurs formes cristallines, et leurs promédicaments. L'invention concerne des procédés de préparation desdits composés, leur utilité dans le traitement d'états cliniques notamment des troubles lipidiques (dyslipidémie), associés ou non à la résistance à l'insuline. L'invention concerne en outre des procédés d'utilisation thérapeutique desdits composés et des compositions pharmaceutiques les contenant.

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