C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/00 (2006.01) C07C 233/33 (2006.01) C07C 235/84 (2006.01) C07C 237/00 (2006.01) C07C 239/00 (2006.01)
Patent
CA 2286252
The present invention relates to a compound of formula (I) wherein X is -CONH- or -NHCO-, or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof. The compounds of the present invention exhibit retinoid-like properties and are thus useful as antiinflammatory agents for chronic skin inflammatory diseases such as psoriasis and atopic dermatitis, as agents for the treatment of rheumatic diseases such as rheumatoid arthritis, as antitumor agents for the treatment of various tumors, and as agents for the treatment of non-malignant proliferative skin conditions.
L'invention concerne un composé de formule (I), dans laquelle X est CONH ou NHCO, ou bien un sel pharmaceutiquement acceptable, un ester ou un solvate, physiologiquement hydrolysable et non toxique, dudit composé. Les composés de la présente invention, qui possèdent des propriétés de type rétinoïde, sont utiles comme agents anti-inflammatoires permettant de traiter les maladies chroniques de la peau telles que le psoriasis et la dermatite atopique, comme agents permettant de traiter les maladies rhumatismales telles que la polyarthrite rhumatoïde, comme agents antitumoraux permettant de traiter diverses tumeurs et comme agents permettant de traiter les troubles prolifératifs cutanés bénins.
Ostrowski Jacek
Reczek Peter R.
Zusi Fred C.
Bristol-Myers Squibb Company
Cassan Maclean
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