Cgrp receptor antagonists

Details Cgrp receptor antagonists Cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 498/20 (2006.01) A61K 31/537 (2006.01) A61K 31/5386 (2006.01) A61P 25/06 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2738657

Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, E a, E b, E c, R6, R7, R e, R f, R PG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache, The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

Composés de formule (I), (dans laquelle les variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y et Z sont telles que décrites dans ce document) utiles en tant quantagonistes des récepteurs CGRP et utiles dans le traitement ou la prévention de maladies dans lesquelles les récepteurs CGRP sont impliqués, telles que des céphalées, et en particulier la migraine et lalgie vasculaire de la face. Linvention concerne également des compositions pharmaceutiques renfermant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de ces maladies dans lesquelles les récepteurs CGRP sont impliqués.

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