2-cyclopenten-1-one and its derivatives as inhibitors of the...

Details 2-cyclopenten-1-one and its derivatives as inhibitors of the... 2-cyclopenten-1-one and its derivatives as inhibitors of the...

A - Human Necessities

61

K

A61K 31/12 (2006.01) A61K 31/122 (2006.01)

Patent

CA 2274108

2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-.kappa.B factor, with anti-inflammatory, anti-proliferative, immuno-suppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect the NF-.kappa.B inhibitory activity.

L'invention concerne le 2-cyclopentène-1-one et ses dérivés comprenant le noyau de cyclopenténone comme inhibiteurs du facteur NF-kB, présentant une activité anti-inflammatoire, anti-prolifère, immunosuppressive, cytoprotectrice et antivirale. Les substituants sont sélectionnés parmi les ones qui ne modifient pas l'activité d'inhibition de NF-kB.

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