Methods for enhancing the efficacy of cancer therapy

Details Methods for enhancing the efficacy of cancer therapy Methods for enhancing the efficacy of cancer therapy

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/203 (2006.01) A61K 38/17 (2006.01) A61K 39/02 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2420867

The invention concerns the identification of tumor antigens the expression of which is selectively upregulated by retinoid treatment. The invention further concerns improved methods of cancer treatment and, in particular, methods enhancing the efficacy of the treatment of cancers characterized by aberrant Wnt signaling by administration of retinoic acid or other retinoids.

La présente invention concerne l'identification d'antigènes de tumeur dont l'expression est régulée à la hausse de façon sélective par traitement aux rétinoïdes. Cette invention concerne aussi des techniques améliorées de traitement contre le cancer et, en particulier, des techniques qui renforcent l'efficacité de traitement contre des cancers caractérisés par une signalisation Wnt aberrante, par l'administration d'acide rétinoïque ou d'autres rétinoïdes.

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