Small interference rna gene therapy

Details Small interference rna gene therapy Small interference rna gene therapy

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2513679

Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.

L'expression génique est inhibée dans une cellule par l'introduction d'un vecteur lentiviral codant pour l'ARNsi spécifique du gène. Les vecteurs lentiviraux codants pour l'ARNsi spécifique de l'expression génique inhibée du gène lié au cancer, induisent la mort des cellules après leur introduction dans des cellules cancéreuses. La réplication virale dans les cellules infectées par le virus HIV est inhibée après l'introduction d'un vecteur lentiviral codant l'ARNsi spécifique aux gènes HIV dans les cellules.

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