C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2478572
The invention relates to the field of biology, genetics and medicine. In particular, the invention relates to novel methods of detecting, characterising and/or treating cancer pathologies, such as prostate cancer. The invention also relates to methods of identifying and screening compounds that are active in said pathologies. Furthermore, the invention relates to compounds, genes, cells, plasmids or compositions that are used to carry out the above-mentioned methods. More specifically, the invention outlines the role of variants of human kallikrein-2 and human kallikrein-3, also known as PSA, in the aforementioned pathologies and the uses of same as therapeutic, diagnostic or experimental targets.
La présente invention concerne le domaine de la biologie, de la génétique et de la médecine. Elle concerne notamment de nouvelles méthodes pour la détection, la caractérisation et/ou le traitement de pathologies cancéreuses, notamment du cancer de la prostate. L'invention concerne également des méthodes pour l'identification ou le criblage de composés actifs dans ces pathologies. L'invention concerne également les composés, gènes, cellules, plasmides ou compositions utiles pour la mise en .oelig.uvre des méthodes évoquées ci-dessus. L'invention décrit notamment le rôle de variants de la kallikréine-2 humaine et de la kallikréine-3 humaine, aussi connue sous le nom de PSA, dans ces pathologies et leurs utilisations comme cibles thérapeutiques, diagnostiques ou expérimentales.
Bracco Laurent
Brinkman Brigitta
Coignard Fanny
Exonhit Therapeutics Sa
Robic
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