(4-acylaminopiperidin-1-yl)acetamides as neurokinin antagonists

Details (4-acylaminopiperidin-1-yl)acetamides as neurokinin antagonists (4-acylaminopiperidin-1-yl)acetamides as neurokinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4468 (2006.01) A61K 31/4525 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61K 31/5355 (2006.01) C07D 211/58 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2425164

The invention relates to new compounds of formula I (see formula I) or the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, X and Ar1 have the meanings given in the specification, as well as the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.

La présente invention concerne de nouveaux composés de formule (I) ou des sels de ceux-ci, acceptables d'un point de vue pharmaceutique. Dans la formule (I), R<1>, R<2>, R<3>, R<4>, X et Ar<1> ont les significations énoncées dans la description. La présente invention concerne également la production et l'utilisation de ces composés. Les nouveaux composés selon cette invention constituent de précieux antagonistes de neurokinine (tachykinine).

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