Cleavage of precursors of insulins by a variant of trypsin

Details Cleavage of precursors of insulins by a variant of trypsin Cleavage of precursors of insulins by a variant of trypsin

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 14/62 (2006.01) C12N 9/76 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2621344

The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non- animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin.

L'invention concerne la production d'un variant de la trypsine recombinée grâce à la spécificité améliorée d'un substrat pour l'arginine versus lysine chez des organismes hôtes non animaux. De plus, l'invention concerne un variant de la trypsine recombinée et sa production, ainsi que l'utilisation de variants de la trypsine pancréatique porcine recombinée destinée au clivage des précurseurs de l'insuline, et des kits contenant le variant de la trypsine.

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