Use of antibodies to sialidase as anti-infectious agents and...

Details Use of antibodies to sialidase as anti-infectious agents and... Use of antibodies to sialidase as anti-infectious agents and...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/35 (2006.01) A61K 31/70 (2006.01) A61K 31/7012 (2006.01) A61K 31/7028 (2006.01) A61K 39/21 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2269533

Sialic acids have the ability to prevent hyposialylation of cells as competitive inhibitors of endogenous sialidase. It is now also possible to develop antibodies to mammalian sialidase that significantly reduce influx of neutrophils into inflammatory sites.

Les acides sialiques ont la capacité d'empêcher l'hyposialylation des cellules en tant qu'inhibiteurs compétitifs de la sialidase endogène. Il est maintenant possible également de mettre au point des anticorps contre la sialidase mammalienne qui réduisent de manière significative l'afflux de neutrophiles sur les sites inflammatoires.

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