Recombinant viruses, preparation and use in genic therapy

Details Recombinant viruses, preparation and use in genic therapy Recombinant viruses, preparation and use in genic therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184200

Recombinant adenoviruses comprising a heterologous DNA sequence coding for brain-derived neurotrophic factor (BDNF), preparation thereof, and use thereof for treating and/or preventing degenerative neurological diseases.

La présente invention concerne des adénovirus recombinants comportant une séquence d'ADN hétérologue codant pour le facteur neurotrophique dérivé du cerveau (BDNF), leur préparation, et leur utilisation pour le traitement et/ou la prévention des maladies neurodégénératives.

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