Piperidine derivatives

Details Piperidine derivatives Piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2557489

The invention relates to the compounds of formula (I), wherein R1, R2, Q, X, Y, m and n are defined as in claim 1. The inventive compounds are potent 5- HT2A antagonists and are suitable for use in the treatment of psychoses, schizophrenia, depression, neurological disorders, memory defects, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders such as bulimia, anorexia nervosa, PMS and/or for positively influencing obsessive-compulsive disorders (OCD).

L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿, Q, X, Y, m et n ont les significations indiquées dans la revendication (1), lesquels composés sont de puissants antagonistes des récepteurs 5-HT¿2A? et sont appropriés pour traiter les psychoses, la schizophrénie, la dépression, les troubles neurologiques, les troubles de la mémoire, la maladie de Parkinson, la sclérose latérale amyotrophique, la maladie d'Alzheimer, la maladie de Huntington, les troubles du comportement alimentaire, tels que la boulimie et l'anorexie nerveuse, ainsi que le syndrome prémenstruel et/ou pour influer positivement sur le comportement obsessionnel (trouble obsessionnel-compulsif, TOC).

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