Combined use of interleukin-10 and cyclosporin for...

Details Combined use of interleukin-10 and cyclosporin for... Combined use of interleukin-10 and cyclosporin for...

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2228379

A combination of interleukin-10 and cyclosporin is used to suppress graft- versus-host disease, autoimmune diseases and tissue/graft rejection. It has been discovered that administration of a combination of interleukin-10 and cyclosporin causes synergistic suppression of T cell proliferation. Concurrent use of both agents avoids the toxicity associated with higher doses of cyclosporin.

L'invention concerne une combinaison d'interleukine-10 et de cyclosporine pour éviter la réaction de la greffe contre l'hôte, le rejet de la greffe par l'hôte et comme traitement contre les maladies auto-immunes. On a découvert que l'administration d'une combinaison d'interleukine-10 et de cyclosporine a un effet synergique d'inhibition de la prolifération des leucocytes T. L'utilisation simultanée de ces deux agents évite les problèmes de toxicité associés avec des doses plus élevées de cyclosporine.

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