C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2659512
Disclosed are novel piperazine derivatives of Formula (I) wherein the variables are as in claim 1 that act as agonists of the alpha7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
La présente invention concerne de nouveaux dérivés de pipérazine qui agissent en tant qu'agonistes de .alpha.7-nAChR. La présente invention concerne en outre des compositions pharmaceutiques, des procédés de traitement de pathologies inflammatoires, des procédés de traitement de troubles du SNC, des procédés d'inhibition de la libération de cytokine par des cellules de mammifère et des procédés pour la préparation des nouveaux composés.
Clark Roger B.
Elbaum Daniel
Cornerstone Therapeutics Inc.
Critical Therapeutics Inc.
Gowling Lafleur Henderson Llp
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