C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 9/00 (2006.01) A61K 39/395 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2629850
The invention relates to dAb monomers that bind IL-1R1 and inhibit binding of IL-1 (e.g., IL-1.alpha. and/or IL-1.beta.) and IL-1ra to IL-1R1, and to ligands comprising such dAb monomers. The invention relates to protease resistand dAb monomers, and to ligands comprising protease resistant dAb monomers. The invention also relates to nucleic acids including vectors that encode the dAb monomers and ligand, to host cells that comprise the nucleic acids and to method for producing a dAb monomer or ligand. The invention also relates to pharmaceutical compositions that comprise the dAb monomers or ligands, and to therapeutic methods that comprise administering a dAb monomer of ligand.
L'invention concerne des monomères dAb qui lient IL-1R1 et inhibent la liaison de IL- 1 (p.ex., IL- 1 a et/ou IL- 1 ß) et de IL- 1 ra à IL- 1R1, et des ligands comprenant ces monomères dAb. L'invention concerne des monomères dAb résistant à la protéase et des ligands comprenant ces monomères dAb résistant à la protéase. L'invention concerne ensuite des acides nucléiques comprenant les vecteurs qui codent les monomères et ligands dAb, des cellules hôtes comprenant les acides nucléiques et un procédé pour produire un monomère ou ligand dAb. L'invention concerne aussi des compositions pharmaceutiques qui comprennent ces monomères ou ligands dAb et des procédés thérapeutiques qui consistent à administrer un monomère ou ligand dAb.
Basran Amrik
de Wildt Rudolf M. T.
Drew Philip D.
Tomlinson Ian M.
Domantis Limited
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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