Vectors for gene delivery

Details Vectors for gene delivery Vectors for gene delivery

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/025 (2006.01) C07K 14/155 (2006.01) C07K 14/535 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2215162

Herpesvirus amplicon preparations comprise an origin of replication, a packaging sequence, and at least one inserted gene under control of a promoter, suitable for use as an immunogen or vaccine, in association with helper herpesvirus or DNA, wherein the associated helper virus is of restricted replication competence in a normal host cell; for example where the associated helper virus has an inactivating defect in respect of a gene essential for production of infectious new virus particles, and where the amplicon carries an inserted gene necessary for the propagation of the helper virus.

Cette invention concerne des préparations d'amplicons d'herpèsvirus qui comportent une origine de réplication, une séquence d'encapsulation, et au moins un gène inséré sous contrôle d'un promoteur, et qui peuvent servir d'immunogène ou de vaccin, en association avec un herpèsvirus assistant ou un ADN, le virus assistant associé ayant une compétence restreinte en matière de réplication dans une cellule hôte normale, ledit virus assistant associé présentant, par exemple, un défaut le rendant inactif vis-à-vis d'un gène essentiel pour la production de particules infectieuses d'un nouveau virus, et l'amplicon portant un gène inséré nécessaire à la propagation du virus assistant.

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