Use of relaxin as adjuvant in the differentiation of stem...

A - Human Necessities – 61 – K

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A61K 38/30 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2549863

On the basis of the experimental results it has emerged that relaxin has a pro- differentiating effect on stem cells. It is therefore suggested the use of this hormone as principal component of a drug for the treatment of all those situations that find or will find benefit from the use of stem cells for the reconstruction of tissues damaged by traumatic events or by ischemic~inflammatory-degenerative diseases. It is also suggested the use of relaxin for the treatment of syndromes deriving from the missing activation of stem cells during fetal development (at subsequent somatic-functional maturation), such as for example hypogonotropic hypogonadism with anosmia (Kallman's syndrome).

Sur la base des résultats d'expériences, on a découvert que la relaxine a un effet favorable sur la différentiation des cellules souches. On propose donc d'utiliser cette hormone en tant que composant principal d'un médicament destiné au traitement de tous les états qui bénéficient ou vont bénéficier de l'utilisation de cellules souches dans la reconstruction de tissus endommagés par des événements traumatiques ou par des maladies ischémiques / inflammatoires / dégénératives. On propose aussi d'utiliser la relaxine dans le traitement des syndromes dus au manque d'activation des cellules souches lors du développement du foetus (pendant la maturation somatique / fonctionnelle subséquente), par exemple, pour l'hypogonadisme hypogonotropique avec l'anosmie (syndrome de Kallman).

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