Antibiotic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 477/00 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2091309

ABSTRACT ANTIBIOTIC COMPOUNDS The present invention relates to carbapenems and provides a compound of the formula (I) Image (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; P is of the formula (IA), (IB) or (IC) Image (IA) (IB) (IC) and in the formula (IB) the naphthyl group may be bonded to the nitrogen of the linking carbamoyl group at either ring; Z is carboxy, sulfonic acid, sulfinic acid, C1-4alkanamidosulfonyl (-SO2NHCOC1-3alkyl), benzamidosulfonyl, C1-4alkylsulfonyl- carbamoyl (-CONHSO2C1-4alkyl), phenylsulfonylcarbamoyl, C1-4alkoxy carbamoyl, hydroxycarbamoyl, sulfoamino, N-C1-4alkanesulfonamido, cyanocarbamoyl, cyanosulfamoyl, tetrazol-5-yl, 3-hydroxyisoxazol-4-yl and 3-hydroxyisoxazol-5-yl; and P is optionally further substituted provided that when P is of the formula (IA) or (IC), Z is not carboxy; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Antibiotic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2071856

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.