Method for in vitro detection of cancers by highlighting...

Details Method for in vitro detection of cancers by highlighting... Method for in vitro detection of cancers by highlighting...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2475680

The invention relates to a method for detection of tumour cells contained in a biological sample by highlighting allelic imbalances in insertion-deletion chromosome markers, said method using multiple amplification of said markers by thermal-dependent chain reaction with calculation of a global statistical score for all studied markers and comparison of said score with a fixed normal threshold.

L'invention a pour objet un procédé de détection des cellules tumorales contenues dans un prélèvement biologique par mise en évidence de déséquilibres alléliques de marqueurs chromosomiques d'insertion~-délétion, ledit procédé faisant appel à l'amplification multiplex desdits marqueurs par réaction en chaîne thermo -dépendante, au calcul d'un score statistique global, sur l'ensemble des marqueurs étudiés, et à la comparaison dudit score par rapport au seuil de normalité fixé.

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