Methods and compositions useful for modulation of...

Details Methods and compositions useful for modulation of... Methods and compositions useful for modulation of...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/45 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2330025

The present invention describes methods for modulating angiogenesis in tissues using Src protein, modified Src protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Src protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Src protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Src protein, or modified forms thereof.

Cette invention a trait à des techniques visant à moduler l'angiogenèse dans des tissus à l'aide de la protéine Src, de cette protéine modifiée et d'acides nucléiques la codant. Elle porte, notamment, sur des techniques d'inhibition de l'angiogenèse à l'aide d'une protéine Src inactive ou d'acides nucléiques la codant ou de potentialisation de l'angiogenèse à l'aide d'une protéine Src active ou d'acides nucléiques la codant. Elle concerne également l'utilisation de système d'apport de gène destiné à fournir des acides nucléiques codant la protéine Src ou ses formes modifiées.

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