C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/06 (2006.01) A01N 43/647 (2006.01)
Patent
CA 2567437
The present invention is directed to certain novel triazole compounds represented by Formula: (I); and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
Cette invention concerne certains nouveaux composés de triazole représentés par des sels, des solvates, des hydrates et des promédicaments de Formule I et acceptables d~un point de vue pharmaceutique. Elle concerne également les méthodes de production et d~emploi de ces composés et des compositions pharmaceutiques les contenant destinées au traitement et au contrôle de maladies déclenchées par des PPAR, telles le métabolisme glucosé, le métabolisme et la sécrétion d~insuline, plus spécialement le diabète du Type 2, l~hyperinsulémie, l~hyperlipidémie, l~hyperuricémie, l~hypercholestérémie, l~athérosclérose, un ou plusieurs facteurs de risque de trouble cardiovasculaire, le Syndrome X, l~hypertriglycéridémie, l~hyperglycémie, l~obésité et les troubles alimentaires.
Cheng Peng
Gregoire Francine M.
Ma Jingyuan
Rakhmanova Vera A.
Zhao Zuchun
Fetherstonhaugh & Co.
Metabolex Inc.
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