Pharmaceutically acceptable starch

Details Pharmaceutically acceptable starch Pharmaceutically acceptable starch

C - Chemistry, Metallurgy

08

B

C08B 30/12 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 47/36 (2006.01) C08B 30/04 (2006.01) C08B 30/20 (2006.01)

Patent

CA 2424888

Production of purified, parenterally administrable starch by washing starch containing more than 85 % amylopectin in order to remove surface-localized proteins, lipids and exdotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, and optionally removal of residual water-soluble proteins, preferably by anion exchange chromatography. Purified starch and microparticles based on such starch.

La présente invention concerne la production d'amidon purifié administrable par voie parentérale par lavage d'amidon contenant plus de 85 % d'amylopectine, dans le but d'éliminer les protéines, les lipides, et les endotoxines localisés en surface par dissolution de l'amidon en milieu aqueux, réduction de la masse moléculaire par cisaillement et éventuellement élimination des protéines solubles dans l'eau, de préférence par chromatographie par échange anionique. La présente invention concerne également l'amidon purifié et les microparticules à base dudit amidon.

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