A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2262765
The present ivention relates to therapeutic combinations of [3R*(1R*,2S*)]-[3- [[(4-aminophenyl)sulphonyl](2-methylpropyl)-amino]-2-hydroxy-1- phenylmethyl)propyl]carbamic acid, tetrahydro-3-furanyl ester (141W94), 3'- azido-3'-deoxythymidine (zidovudine) and (1S,4R)-cis-4-[2-amino- 6(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89) which have anti-HIV activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.
L'invention concerne des combinaisons thérapeutiques d'acide [3R*(1R*,2S*)]-[3[[(4-aminophényl)sulfonyl](2-méthylpropyl)-amino]-2-hydroxy-1-phénylméthyl)propyl]carbamique, d'ester tétrahydro-3-furanyl (141W94), 3'-azido-3'-désoxythymidine (zidovudine) et (1S,4R)-cis-4-[2-amino-6(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentène-1-méthanol (1592U89) qui exercent une activité contre le VIH. La présente invention traite aussi de compositions pharmaceutiques renfermant ces combinaisons et leurs utilisations pour traiter les infections par le VIH, y compris par les mutants du VIH offrant une résistance aux inhibiteurs nucléosides et/ou non nucléosides.
Barry David Walter
St. Clair Martha Heider
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
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