C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2609999
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF.alpha., which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF.alpha., and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF.alpha.-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Anticorps scFv particulièrement stables et solubles et fragments Fab spécifiques au TNFa, comprenant des séquences spécifiques de chaîne légère et de chaîne lourde optimisées en termes de stabilité, solubilité, liaison in vitro et in vivo du TNFa et faible immunogénicité. Ces anticorps sont appropriés au diagnostic et/ou au traitement des troubles liés au TNFa. On décrit aussi les acides nucléiques, vecteurs et cellules hôtes pour l'expression des anticorps de recombinaison considérés dans l'invention, des procédés d'isolation correspondants et l'utilisation de ces anticorps en médecine.
Auf Der Maur Adrian
Barberis Alcide
Ewert Stefan
Lichtlen Peter
Urech David M.
Esbatech An Alcon Biomedical Research Unit Llc
Esbatech Ag
Smart & Biggar
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