C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2403344
The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non- human mammal. Embodiments of the methods include introducing donor genetic material into a metaphase I oocyte; introducing donor genetic material into a non-enucleated oocyte; introducing donor genetic material obtained from a donor cell that is at metaphase into an oocyte; introducing donor genetic material into an oocyte, and naturally activating the oocyte or the NT embryo; and introducing donor genetic material obtained from a donor cell that is at late G1 phase into an oocyte.
L'invention concerne des procédés de production d'un embryon par transfert de matériel nucléaire (NT) de mammifère non humain cloné ainsi que des procédés de production de mammifère non humain cloné. Des réalisations de ces procédés comprennent l'introduction de matériel génétique donneur dans un oocyte en métaphase I, l'introduction de matériel génétique donneur dans un oocyte non énucléé, l'introduction, dans un oocyte, de matériel génétique donneur provenant d'une cellule de donneur en métaphase, l'introduction de matériel génétique donneur dans un oocyte et activation naturelle de l'oocyte ou de l'embryon NT, et l'introduction, dans un oocyte, de matériel génétique donneur provenant d'une cellule de donneur se trouvant dans une phase G1 tardive.
Smart & Biggar
Stice Steven
The University Of Georgia Research Foundation Inc.
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