Isolation of taxanes

Details Isolation of taxanes Isolation of taxanes

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2428654

An improved method for the isolation of taxanes of high priority from the crude extract of naturally occurring Taxus canadensis which comprises the steps of: a) filtering the crude extract by liquid column chromatography; b) enriching the taxanes obtained from step a) by precipitation and crystallization; c) separating the taxanes obtained from step a) by liquid column chromatography; and d) dissolving the separate taxanes in a polar organic solvent mixture comprising an alcohol and a non-alcohol solvent, which solution is then subjected to further separation by liquid column chromatography, and isolating substantially pure paclitaxel from cephalomannine; and all solvent mixtures used may be collected, purified and recycled without separation.

L'invention porte sur un procédé amélioré visant à isoler des taxanes de haute pureté d'un extrait de pétrole brut de <i>Taxus canadensis</i> d'origine naturelle. Ce procédé consiste à a) filtrer l'extrait de pétrole brut par chromatographique en phase liquide ; b) enrichir les taxanes obtenus à l'étape a) par précipitation et cristallisation; c) séparer les taxanes obtenus à l'étape a) par chromatographie en phase liquide ; et d) dissoudre les taxanes séparés dans un mélange de solvant organique polaire comprenant un solvant alcoolique et un solvant sans alcool, cette solution étant soumise à une autre séparation par chromatographie en phase liquide, et isoler le paclitaxel pratiquement pur de la céphalomannine; et tous les mélanges de solvants utilisés peuvent être récupérés, purifiés et recyclés sans séparation.

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