Immunogens and corresponding antibodies specific for high...

Details Immunogens and corresponding antibodies specific for high... Immunogens and corresponding antibodies specific for high...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/28 (2006.01) A61K 38/47 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2498407

Compositions of matter that comprise one or more conformational epitopes found on amyloid peptide aggregates, antibodies to such epitopes and methods for making and using the compositions, eptitopes and/or antibodies. The invention includes synthetic or isolated compositions that contain or consist of certain conformational epitopes that are found on peptide aggregates (e.g., toxic peptide aggregates) present in human or veterinary patients who suffer from, or who are likely to develop, amyloid diseases (e.g., Alzheimer's Disease). The invention includes methods for the detection, treatment and prevention of diseases in humans or animals, using such compositions. The invention further includes antibodies which bind to the conformational epitopes as well as methods for making such antibodies and methods for the detection, treatment and prevention of diseases and/or identification of potential therapies (e.g., drug screening) using such antibodies.

Compositions comprenant un ou plusieurs déterminants antigéniques de conformation découverts sur des agrégats peptidiques amyloïdes, anticorps contre ces déterminants antigéniques et méthode de préparation et d'utilisation de ces compositions, déterminants antigéniques et/ou anticorps. L'invention concerne des compositions synthétiques ou isolées contenant certains déterminants antigéniques de conformation ou constituées par ces derniers qu'on a découvert sur des agrégats peptidiques (par exemple, des agrégats peptidiques toxiques) présents chez des patients humains ou animaux atteints ou susceptibles d'être atteints par des maladies amyloïdes, par exemple la maladie d'Alzheimer. Elle concerne des méthodes de détection, de traitement et de prévention de maladies chez l'homme ou chez l'animal au moyen de ces compositions. Elle concerne, de plus, des anticorps se liant à ces déterminants antigéniques de conformation, ainsi que des méthodes de préparation de ces anticorps et des méthodes de détection, de traitement et prévention de maladies et/ou d'identification de thérapies potentielles, par exemple, criblage de médicaments, au moyen de ces anticorps.

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