Substituted propylamine derivatives and methods of their use

Details Substituted propylamine derivatives and methods of their use Substituted propylamine derivatives and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61P 25/00 (2006.01) C07D 209/96 (2006.01) C07D 235/26 (2006.01) C07D 235/30 (2006.01) C07D 277/68 (2006.01)

Patent

CA 2623423

The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

L'invention concerne des dérivés de propylamine substituée représentés par la formule (I), ou un sel de ceux-ci acceptable sur le plan pharmaceutique, des compositions qui contiennent ces dérivés, ainsi que des procédés d'utilisation de ces dérivés dans la prévention et le traitement d'états pathologiques qui s'améliorent avec la recaptage de la monoamine, notamment les symptômes vasomoteurs (VMS), la dysfonction sexuelle, les troubles gastro-intestinaux et urogénitaux, le syndrome de fatigue chronique, le syndrome de la fibromyalgie, les troubles du système nerveux, ainsi que des combinaisons de ceux-ci, particulièrement les états pathologiques sélectionnés dans le groupe comprenant le trouble dépressif majeur, les symptômes vasomoteurs, le stress et l'incontinence urinaire d'urgence, la fibromyalgie, la douleur, la neuropathie diabétique, et des combinaisons de ceux-ci.

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