Method of inducing proliferation of retinal stem cells

A - Human Necessities – 61 – K

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Details

A61K 45/00 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 17/00 (2006.01) C12N 5/06 (2006.01) G01N 33/567 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2452233

The present invention relates to a method for promoting the proliferation of retinal stem cells using IL-17B. IL-17B is put into a cell culture medium containing retinal stem cells to promote the proliferation and/or differentiation of retinal stem cells. The retinal stem cells can then be transplanted into the retina to promote the growth of the photoreceptor cells, the rods and the cones. Also IL-17B can be administered directly into the retina to promote the proliferation and/or differentiation of the retinal stem cells.

L'invention concerne un procédé permettant de promouvoir la prolifération de cellules souches rétiniennes à l'aide d'IL-17B. IL-17B est introduit dans un milieu de culture cellulaire contenant des cellules souches rétiniennes pour promouvoir la prolifération et/ou la différenciation de cellules souches rétiniennes. Ces cellules souches rétiniennes peuvent ensuite être transplantées dans la rétine pour promouvoir la croissance de cellules photoréceptrices, des bâtonnets et des cônes. En outre, IL-17B peut être introduit directement dans la rétine pour promouvoir la prolifération et/ou la différenciation des cellules souches rétiniennes.

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