Method of administering conjugates

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2705808

The invention relates to a method of treating a host animal to eliminate pathogenic cells. The method comprises the steps of administering to the host animal a hapten-carrier conjugate, administering to the host animal a TH-I biasing adjuvant, and administering to said host animal a ligand conjugated to a hapten herein the ligand-hapten conjugate is administered during the first cycle of therapy with the hapten-carrier conjugate. The invention also relates to the same method wherein the ratio of the hapten-carrier conjugate to the TH-I biasing adjuvant on a weight to weight basis ranges from about 1: 10 to about 1:1.

La présente invention a pour objet un procédé de traitement d'un animal hôte pour éliminer des cellules pathogènes. Le procédé comprend les étapes consistant à administrer à l'animal hôte un conjugué haptène-support, à administrer à l'animal hôte un adjuvant biaisant la voie Th-1 et à administrer au dit animal hôte un ligand conjugué à un haptène; ici, le conjugué ligand-haptène est administré au cours du premier cycle de thérapie avec le conjugué haptène-support. L'invention concerne également le même procédé dans lequel le rapport du conjugué haptène-support sur l'adjuvant biaisant la voie Th-1 sur une base de poids sur poids se situe dans la plage d'environ 1:10 à environ 1:1.

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