Novel hedgehog-derived polypeptides

Details Novel hedgehog-derived polypeptides Novel hedgehog-derived polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2206509

The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G~CF site recognized by the autoproteolytic domain in the native protein. Also provided are methods of use of the N and C fragments.

Deux nouveaux polypeptides, appelés respectivement fragments "N" et "C" , ou fragments N-terminal et C-terminal, obtenus après clivage spécifique au niveau du site G~CF, reconnu par le domaine autoprotéolytique dans la protéine native. L'invention présente également des méthodes d'utilisation des fragements N et C.

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