Micro-rna's that regulate muscle cells

Details Micro-rna's that regulate muscle cells Micro-rna's that regulate muscle cells

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2603881

The present invention describes microRNAs that regulate the differentiation, proliferation and death of cardiac and skeletal muscles cells. These molecules represent unique targets in the developmental pathways of muscle cells. They also can be used as active agents to induce differentiation in progenitor cells, and their down-regulation permits the maintenance and expansion of progenitor cell populations.

L'invention concerne des microARN qui régulent la différenciation, la prolifération et la mort de cellules du muscle cardiaque et de muscles du squelette. Ces molécules sont des cibles uniques dans les voies de développement des cellules musculaires. Elles peuvent également servir d'agents actifs pour induire une différenciation dans des cellules progénitrices et la diminution de leur nombre autorise le maintien et l'expansion de populations de cellules progénitrices.

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