Preparation of polymer conjugates of therapeutic,...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2651500

This invention provides an improved synthesis of polymer conjugates of formula (I), of agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using "Mitsunobu" or related reaction conditions.

L'invention porte sur la synthèse améliorée de polymères conjugués de formule (I) de composés à caractère agricole, thérapeutique, ou d'additifs alimentaires, et en particulier sur un procédé de préparation de polymères conjugués par traitement de substituts d'alcool primaire ou secondaire de composés actifs par des nucléophiles polymères dans des conditions de réaction de "Mitsunobu" ou apparentées.

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