Anticholinergic agents

Details Anticholinergic agents Anticholinergic agents

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/695 (2006.01) C07D 207/04 (2006.01) C07D 207/06 (2006.01) C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 211/08 (2006.01) C07D 211/14 (2006.01) C07D 211/22 (2006.01) C07D 211/60 (2006.01) C07D 211/66 (2006.01) C07D 211/70 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2072575

Selective muscarinic receptor antagonists of formula (I), wherein R1 and R2 are both optionally substituted phenyl, the broken line is an optional bond, X is (a), (b) or CH- when the double bond is absent or is (c) when the double bond is present, X being attached to a carbon atom of A, A is selected from certain piperidine and pyrrolidine groups, n is 1 to 3 and R3 is optionally substituted phenyl or thienyl, pyridyl or pyrazinyl.

On décrit des antagonistes sélectifs de récepteurs muscariniques de formule (I), où R1 et R2 sont tous deux phényle facultativement substitué, les traits interrompus désignent une liaison facultative, X est (a), (b) ou CH- lorsque la liaison double est absente ou (c) quand la liaison double est présente, X étant lié à un atome de carbone d'A, A est choisi parmi certains groupes pipéridine et pyrrolidine, n est 1 à 3 et R3 est phényle ou thiényle, pyridyle ou pyrazinyle facultativement substitué.

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