Process for preparing macrocyclic compounds

Details Process for preparing macrocyclic compounds Process for preparing macrocyclic compounds

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) C07D 401/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2600367

Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

L'invention concerne un procédé de fabrication d'un composé macrocyclique représenté par la formule (I), dans lequel on fait réagir un composé macrocyclique substitué hyddroxyle de formule (3) avec un composé substitué sulfonyle de formule QUIN. Les composés de formule (I) sont des principes actifs puissants pour le traitement de l'infection par le virus de l'hépatite C (VHC).

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