C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/46 (2006.01) A61K 49/04 (2006.01) C07D 207/26 (2006.01)
Patent
CA 2100338
- 65 - ABSTRACT The invention refers to new iodinated, non-ionic X-ray contrasting agents with a dimeric structure with the general formula I, in which the bridging link is glycine or an N- substituted glycine Image I where R1 is a linear or branched polyhydroxyalkyl of 2 to 4 carbon atoms, R2 is a hydrogen, methyl or linear polyhydroxyalkyl residue of 2 to 3 carbon atoms, R3 and R8, which may be the same or different are hydrogen, methyl or 2- hydroxyethyl, R4 is a linear or branched polyhydroxylalkyl of 2 to 4 carbon atoms, R5 is methyl, hydroxymethyl or methoxymethyl, and R6 and R7 which may be the same or different are hydrogen, methyl, hydroxyethyl or 2,3- dihydroxypropyl, R2 and R5 together being able to form a group of the type where n may be from 0 to 3. The invention also refers to procedures for the obtention of products of formula I, and preparations which are pharmaceutically acceptable that contain these products.
Carretero Colon Jose Ma
Harto Martinez Juan R.
Martin Jimenez Jose L.
Martinez Sanz Antonio
Silva Ignacio Alonso
Centro Investigacion Justesa Imagen S.a.
Ridout & Maybee Llp
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