The myostatin gene promoter and inhibition of activation...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2375820

The subject invention relates to a promoter which induces expression of the myostatin gene as well as to methods for identifying compositions useful for the inhibition of the promoter, and also methods and compositions useful for preventing the synthesis, secretion and function of myostatin. In particular, inhibitors that prevent the synthesis, secretion and function of myostatin may be used to prevent the loss of muscle mass in humans and animals.

L'invention concerne un promoteur induisant l'expression du gène de la myostatine. Elle concerne des méthodes pour identifier des compositions pouvant inhiber efficacement le promoteur, ainsi que des méthodes et des compositions pouvant empêcher efficacement la synthèse, la sécrétion et la fonction de la myostatine. Plus particulièrement, des inhibiteurs empêchant la synthèse, la sécrétion et la fonction de la myostatine peuvent être employés pour prévenir la perte de masse musculaire chez les humains et les animaux.

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