C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6553 (2006.01) C07B 37/04 (2006.01) C07F 9/40 (2006.01) C07F 9/50 (2006.01) C07F 9/53 (2006.01) C07F 9/547 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2256828
A process for the manufacture of bisphosphine oxide compounds and bisphospho- nates as intermediates for the production of bisphosphine ligands, in which in a single step process a) a phosphine oxide compound is reacted in an organic solvent at -70°C to 20°C with 0.5-3 eq. of a lithium or magnesium amide compound, b) 0.5-3 eq. of oxidatively-acting metal salt or metal salt complex are added to the suspension obtained in stage a) in a temperature range of -70°C to 20°C, with a racemate of a bisphosphine oxide compound being obtained; c) a racemate cleavage is carried out if desired; and d) the bisphosphonates obtained in stage b) or c) are converted into bisphosphine oxides.
Foricher Joseph
Schmid Rudolf
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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