Topical antiinflammatory compositions with minimal systemic...

Details Topical antiinflammatory compositions with minimal systemic... Topical antiinflammatory compositions with minimal systemic...

A - Human Necessities

61

K

A61K 31/045 (2006.01) A61K 31/40 (2006.01) A61K 47/10 (2006.01) C07C 39/14 (2006.01) C07C 49/835 (2006.01) C07C 49/84 (2006.01) C07C 69/732 (2006.01)

Patent

CA 2064189

2064189 9103227 PCTABS00003 Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds.

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