A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01) A61K 9/127 (2006.01) A61K 38/28 (2006.01) A61M 11/00 (2006.01)
Patent
CA 2353848
A mixed liposome pharmaceutical formulation with multilamellar vesicles, comprises a proteinic pharmaceutical agent, water, an alkali metal lauryl sulphate in a concentration of from 1 to 10 wt./wt.%, at least one membrane- mimetic amphiphile and at least one phospholipid. The amount of each membrane mimetic amphiphile and phospholipid is present in a concentration of from 1 to 10 wt./wt.% of the total formulation, and the total concentration of membrane mimetic amphiphiles and phospholipids is less than 50 wt./wt.% of the formulation. The formulation may be administered to the buccal cavity using a metered dose dispenser.
L'invention concerne une formule pharmaceutique à base de liposomes mélangés, comprenant des vésicules multilamellaires, qui comporte un agent pharmaceutique protéinique, de l'eau, et un sulfate laurique de métal alcalin, à raison de 1 à 10 % en poids, au moins un amphiphile imitant une membrane et au moins un phospholipide. La proportion d'amphiphiles imitant une membrane et de phospholipides varie de 1 à 10 % en poids de la formule totale, et la concentration totale d'amphiphiles imitant une membrane et de phospholipides est inférieure à 50 % en poids de la formule. Ladite formule peut être administrée dans la cavité buccale au moyen d'un distributeur doseur.
Generex Pharmaceuticals Inc.
Perry + Currier
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