Preparation of 2-(2'-thienyl)alkylamines and derivatives...

C - Chemistry – Metallurgy – 07 – D

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260/276.1, 260/3

C07D 333/20 (2006.01) C07D 333/24 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2034929

26790/26940-FF ABSTRACT OF THE DISCLOSURE An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

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