Methods of making and using nano scale particles

Details Methods of making and using nano scale particles Methods of making and using nano scale particles

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2688164

The instant invention discloses methods of preparing phospholipid delivery systems encapsulating one or more bio-affecting compounds, said methods comprising solubilizing a heterogeneous phospholipid mixture into a suitable organic solvent to form a concentrated formulation of phospholipids, wherein the phospholipids comprise a charged phospholipid species, and mixing the concentrated formulation with an aqueous solution comprising at least one bio-affecting compound. The instant invention also discloses methods of using a phospholipid delivery system encapsulating at least one bio-affecting compound for administration to an individual in need thereof.

L'invention concerne des procédés de préparation de systèmes d'administration de phospholipide encapsulant un ou plusieurs composés bioeffecteurs, lesdits procédés comprenant la solubilisation d'un mélange de phospholipides hétérogène dans un solvant organique approprié pour former une formulation concentrée de phospholipides, les phospholipides comprenant une espèce de phospholipide chargée, et le mélange de la formulation concentrée avec une solution aqueuse comprenant au moins un composé bioeffecteur. La présente invention concerne également des procédés d'utilisation d'un système d'administration de phospholipide encapsulant au moins un composé bioeffecteur pour l'administration à un individu qui en a besoin.

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