Propofol for treatment of sepsis

Details Propofol for treatment of sepsis Propofol for treatment of sepsis

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 9/107 (2006.01) A61K 47/10 (2006.01) A61K 47/24 (2006.01) A61K 47/44 (2006.01) A61P 7/08 (2006.01)

Patent

CA 2407540

The invention relates to a method of managing septic shock and counteracting endotoxin induced deterioration of arterial oxygen tension which comprises administration of an effective amount of a sterile pharmaceutical composition for parenteral administration, which composition comprises the compound 2,6- diisopropylphenol (propofol) in association with a sterile pharmaceutically- acceptable diluent or carrier, and the use of such a sterile pharmaceutical composition for use as a medicament for managing septic shock, and the use of such a sterile pharmaceutical composition for the manufacture of a medicament for the management of septic shock and for counteracting endotoxin induced deterioration of arterial oxygen tension.

La présente invention concerne un procédé de gestion de choc septique et de neutralisation d'une dégradation de la tension en oxygène des artères provoquée par une endoxine. Ce procédé consiste à administrer une quantité efficace d'une composition pharmaceutique stérile par voie parentale. Cette composition comprend le composé 2, 6- diisopropylphénol (propofol) associé à un diluant ou à un excipient stérile pharmaceutiquement acceptable. Cette invention concerne aussi l'utilisation de cette composition pharmaceutique stérile sous forme de médicament destiné à la gestion du choc septique, et l'utilisation de cette composition pharmaceutique stérile dans la fabrication d'un médicament destiné à la gestion du choc septique et à la neutralisation d'une dégradation de la tension en oxygène des artères provoquée par une endoxine.

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