Cetp inhibitors

Details Cetp inhibitors Cetp inhibitors

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/27 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2625988

Compounds having a biphenyl group substituted with a phenyl or heteroaromatic group, as shown in Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL- cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:

L'invention concerne des composés comportant un groupement biphényle substitué par un groupement phényle ou hétéroaromatique, représentés par la Formule I, y compris des sels de qualité pharmaceutique desdits composés, qui sont des inhibiteurs de CETP et qui peuvent être employés pour augmenter la teneur en cholestérol HDL, réduire la teneur en cholestérol LDL, et traiter ou prévenir l'athérosclérose :

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