Method and apparatus for identification of biological material

Details Method and apparatus for identification of biological material Method and apparatus for identification of biological material

H - Electricity

01

J

H01J 49/16 (2006.01) G01N 1/38 (2006.01) G01N 15/14 (2006.01) H01J 49/04 (2006.01)

Patent

CA 2734760

Biological material is detected in a sample using a MALDI-MS technique (Matrix Assisted Laser Desorption and Ionization-Mass Spectroscopy). A liquid comprising the sample and a MALDI matrix material is prepared and used to form a continuous stream of the liquid. The stream is separated into successive parts to form drops, which are launched into flight, or the stream is launched into flight and then separated into drops. Drop forming techniques maybe used that are known from ink jet printers. Material from the drops is ionized while in flight. Mass spectra from the ionized material of respective drops are measured. Preferably, before the drops are formed the liquid is diluted to a level where the majority of drops at most one micro-organism is present per drop.

Selon l'invention, un matériel biologique est détecté dans un échantillon en utilisant une technique MALDI-MS (désorption-ionisation laser assistée par matrice - spectroscopie de masse). Un liquide comprenant l'échantillon et un matériau de matrice MALDI est préparé et utilisé pour former un flux continu du liquide. Le flux est séparé en parties successives pour former des gouttes, qui sont lancées en vol, ou le flux est lancé en vol et ensuite séparé en gouttes. Des techniques de formation de gouttes peuvent être utilisées qui sont connues d'après les imprimantes à jet d'encre. Le matériau des gouttes est ionisé en vol. Des spectres de masse du matériau ionisé de gouttes respectives sont mesurés. De préférence, avant que les gouttes soient formées, le liquide est dilué à un niveau auquel, pour la majorité des gouttes, au plus un microorganisme est présent par goutte.

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