Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives,...

Details Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives,... Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2624102

The invention relates to phenyl-1,2,4-oxadiazolone derivatives in all its stereoisomeric forms and mixtures in any ratio, and its physiologically acceptable salts and tautomeric forms showing PPARdelta agonist activity. What is described are compounds of the formula (I), wherein the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

L'invention concerne des dérivés de phényl-1,2,4-oxadiazolone sous toutes leurs formes stéréoisomères et leurs mélanges dans des proportions quelconques, ainsi que les sels physiologiquement acceptables et les formes tautomères de deux-ci qui exercent une activité agoniste sur les récepteurs PPAR.DELTA.. L'invention décrit ainsi des composés représentés par la formule (I), dans laquelle les radicaux sont tels que définis dans la description, ainsi que les sels physiologiquement acceptables de ceux-ci et les procédés utilisés pour les obtenir. Ces composés sont utilisés pour traiter et/ou prévenir les troubles du métabolisme des acides gras, les troubles de l'utilisation du glucose, les troubles impliquant l'insulinorésistance et la démyélinisation, ainsi que d'autres troubles neurodégénératifs du système nerveux central et périphérique.

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